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A Rare Case of Amyloid Goiter Suspected to Be Malignant on Imaging Findings

Year: 2025

Type: article

Abstract: A 67-year-old man was diagnosed with Hashimoto's thyroiditis, and replacement therapy with levothyroxine was initiated. Ten years later, although the patient was euthyroid, ultrasonography showed an increase in goiter size and a significant decrease in overall echogenicity with scattered high-echo areas. Computed tomography revealed diffuse low-density areas with no contrast effect in the thyroid parenchyma and partial high-density areas, indicating possible malignancy. However, a core needle biopsy revealed an amyloid light-chain (AL) κ-type amyloid goiter. Because serum immunoprecipitation electrophoresis showed IgG κ-type M-protein, the diagnosis was secondary amyloidosis. It is important to consider amyloid goiter with imaging findings, as in this case.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.5426-25

Authors: Masahiro Ichikawa, Nami Suzuki, Natsuko Watanabe, Tatsuya Iida, Toshino Suzuki, Masakazu Koshibu, Rei Hirose, Masako Matsumoto, Miho Fukushita, Ai Yoshihara, Jaeduk Yoshimura Noh, Kiminori Sugino, Ryohei Katoh, Koichi Ito

Institution: Ito Hospital

Language: English

Topic: Amyloidosis: Diagnosis, Treatment, Outcomes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416711961

FWCI:

Cites: 12

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