Selpercatinib-induced Acalculous Cholecystitis in an Elderly Patient with RET Fusion-positive Non-small Cell Lung Cancer
Year: 2025
Type: article
Study design: Case Report
Abstract: The effectiveness of selpercatinib against RET-fusion-positive non-small cell lung cancer (NSCLC) in geriatric patients is underreported. We report the case of an 84-year-old woman in whom reduced-dose selpercatinib elicited a significant tumor response in KIF5B-RET fusion-positive NSCLC. However, she developed acalculous cholecystitis, which led to the discontinuation of the drug. This is the first reported case of selpercatinib-induced acalculous cholecystitis in a patient. The report highlighted the potential efficacy of selpercatinib in elderly patients while underscoring the risk of severe adverse events and emphasizing monitoring and personalized dose management.
Source: Internal Medicine
Authors: Takeru Ichikawa, Ken Sato, Yuto Sasano, Shoichiro Matsumoto, Suzuka Matsuoka, Yuki Takigawa, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Keiichi Fujiwara, Takuo Shibayama
Institution: Okayama Medical Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416712055