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Particulate matter increases bone morphogenetic protein 2 in lung fibroblasts

Year: 2025

Type: article

Abstract: Particulate matter <2.5 µm (PM 2.5 ) from air pollution contributes to many different lung diseases, but the mechanisms are not fully understood. Here, we demonstrated that PM 2.5 caused an upregulation of bone morphogenetic protein 2 (BMP2) in lung fibroblasts. BMP2 can promote myofibroblast differentiation or inhibit collagen expression, depending on the context, and can be a means by which PM 2.5 contributes to fibrotic and nonfibrotic lung diseases.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00224.2025

Authors: Nathan Craig, Jack P. Berens, Eistine Boateng, Anne M. Scruggs, Julia J. Khater, Yahong Chen, Furong Deng, Steven K. Huang

Institutions: University of Michigan, Michigan Medicine, Peking University Third Hospital, Peking University

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research

Awards: G2180500718, G5675103590, The Role of KCNMB1 and the Large Conductance Potassium (BK) Channel in Myofibroblast Differentiation and Pulmonary Fibrosis, G6582569294, Heterogeneity and Regulation of the DNA Methylome in IPF Mesenchymal Cells

OpenAlex ID: W4416713192

FWCI:

Cites: 52

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