Work

Evaluation of the dynamic patterns of sFlt−1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management

Year: 2025

Type: article

Abstract: Objective To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility.Methods Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) women with PE were included, from which 19, 21 and 35 developed early-onset (EPE), late-onset (LPE) and severe-LPE (SLPE) preeclampsia, respectively. Thirty-five (n = 35) women with normotensive pregnancy (NP) served as the reference group.Results In all subgroups of PE, PlGF decreased from diagnosis to peripartum. In contrast, sFlt−1 and the ratio rose in LPE and SLPE subgroups, whereas they remained continuously higher and stable in the EPE subgroup. In all subgroups, postpartum concentrations decreased compared to pregnancy levels. Post-term NP had higher sFlt−1 and ratio, and lower PlGF in comparison to term and late-term NP. Preeclamptic pregnancies complicated with fetal growth restriction (FGR) had continuously higher and stable sFlt−1 concentrations and ratio, and lower PlGF concentrations compared to PE without FGR. Different patterns of the three biomarker trajectories were observed in a case-by-case analysis.Conclusion Further research is warranted to refine pattern analysis and to integrate trajectories of these biomarkers into clinical practice towards personalized care in preeclampsia management.

Source: Hypertension in Pregnancy

DOI: 10.1080/10641955.2025.2579976