Year: 2025
Type: article
Abstract: BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology - aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in bone and calcium endocrinology was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups. RESULTS: Research priorities encompass primary hyperparathyroidism, chronic hypoparathyroidism, and rare calcium-phosphate disorders. Key areas include bone as endocrine organ, bone mass acquisition, secondary osteoporosis, and skeletal dysplasias. Special emphasis is placed on cellular senescence, sex-specific differences in disease manifestation, and development of novel diagnostic tools for bone quality assessment. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into metabolic bone disease pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
Source: Hormone Research in Paediatrics
DOI: 10.1159/000549160
Authors: Katharina Jähn-Rickert, Karin Zibar Tomšić, Athanasios D. Anastasilakis, Jean-Philippe Bertocchio, Maria Luisa Brandi, Martin Fassnacht, Moira Shang-Mei Cheung, Evelien Gevers, Neil Gittoes, Outi Mäkitie, Gabriel Ángel Martos-Moreno, Petar Milovanovic, Adalbert Raimann, Michaela Tencerova, Elena Tsourdi, Annegreet G. Vlug, Wolfgang Högler, Peter Kamenický
Institutions: Universität Hamburg, University Medical Center Hamburg-Eppendorf, University Cancer Center Hamburg, University Hospital Centre Zagreb, 424 General Military Hospital, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Vita-Salute San Raffaele University, University of Würzburg, Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Great Ormond Street Hospital, Queen Mary University of London, William Harvey Research Institute, University of Birmingham, Karolinska University Hospital, University of Helsinki, Helsinki University Hospital, Karolinska Institutet, Helsinki Children's Hospital, Instituto de Salud Carlos III, Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red, Universidad Autónoma de Madrid, University of Belgrade, Medical University of Vienna, Czech Academy of Sciences, Czech Academy of Sciences, Institute of Physiology, Technische Universität Dresden, Leiden University, Leiden University Medical Center, OLVG, Johannes Kepler University of Linz, Inserm, Université Paris-Saclay, Bicêtre Hospital, Physiologie et Physiopathlogie Endocriniennes
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416715707