Work

Mechanochemistry: A Transformative Technique for the Synthesis of Polar Organometallics from Zero‐Valent Metals

Year: 2025

Type: article

Abstract: The generation and synthetic applications of polar organometallic reagents have traditionally relied on organic solvents. Recently, mechanochemistry has emerged as a conceptually new approach in the field, using mechanical forces for the activation of bulk zero-valent metals and enabling a solvent-free or solvent-minimized synthesis of polar organometallics. This transformative approach brings several advantages over traditional methods, such as eliminating the need for strictly anhydrous conditions and inert atmospheres, removing solvent compatibility issues, and improving the reactivity profiles of polar organometallic reagents, thereby addressing long-standing challenges in the field. This concept article brings into focus the key developments in the mechanochemical generation of polar organometallics (derivatives of zinc, magnesium, calcium, barium, and lithium), highlighting the main advantages of this approach and emphasizing the current challenges.

Source: ChemPlusChem

DOI: 10.1002/cplu.202500445

Authors: Jagadeesh Varma Nallaparaju, Riina Aav, Dzmitry Kananovich

Institution: Tallinn University of Technology

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Eesti Teadusagentuur, Haridus- ja Teadusministeerium

Awards: Self-assembled Chiral Hemicucurbiturils as a Versatile Platform for Supramolecular Sensing and Separation of Chiral Compounds, Centre of Excellence in Circular Economy for Strategic Mineral and Carbon Resources, G6744358363, Adaptable supramolecular chirality sensors