Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques
Year: 2025
Type: article
Abstract: Cortical spreading depolarization (CSD) is a pathophysiological event critically implicated in ischemic stroke and other brain disorders. It consists of slowly propagating waves of massive neuronal and glial depolarization in cerebral gray matter, accompanied by spreading depression of cortical activity. CSD disrupts ion homeostasis, alters cerebral blood flow, and contributes to neuronal death in vulnerable tissue. This comprehensive review summarizes both classic and recent studies on CSD mechanisms and their role in brain damage progression after stroke. We also review potential neuroprotective strategies to mitigate CSD-induced damage and discuss available technologies for detecting CSD. Advancing our understanding of CSD mechanisms, combined with targeted neuroprotective strategies and improved monitoring techniques, holds promise for reducing stroke-related brain injury and guiding personalized recovery approaches.
Source: GeroScience
Institutions: Universitat Autònoma de Barcelona, Consejo Superior de Investigaciones Científicas, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro Nacional de Microelectrónica, Institut de Microelectrònica de Barcelona, Institut Català de Nanociència i Nanotecnologia, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red, Centro de Investigación en Red en Enfermedades Cardiovasculares, Corporació Sanitària Parc Taulí, Institute of Research and Innovation Parc Tauli
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,890
Funders: Ministerio de Ciencia, Innovación y Universidades, European Commission, Generalitat de Catalunya, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, HORIZON EUROPE Framework Programme, Instituto de Salud Carlos III, Agencia Estatal de Investigación
Awards: G1039312466, G109329297, G1433347963, G1610934229, G190797785, G1908381382, G2099206364, G2403553946, G2438242660, G2478318928, G2640929160, G295035547, G3480869486, G3724564097, G4364548135, G4688926727, G499301032, G5080475149, G5635532810, G5896532405, G6731524417, G6874468849, G6988416435, G729002392, G7652802932, G7805626310, G8186266869, G8219897552, G8489094949
OpenAlex ID: W4416716714