Work

A noncanonical polyamine from bacteria antagonizes host mitochondrial function

Year: 2025

Type: article

Abstract: Polyamines produced by gut bacteria have been proposed to contribute to inflammatory bowel diseases. Here, Nauta et al. show that bacteria can produce a noncanonical polyamine intermediate that functions similarly to deoxyhypusine synthase inhibitors, activates mitochondrial stress responses, and inhibits nematode development and mouse macrophage differentiation.

Source: Nature Communications

DOI: 10.1038/s41467-025-66499-w

Authors: Kelsie M. Nauta, Darrick R. Gates, Matthew Weiland, Marco E. Mechan-Llontop, Xiao Wang, Christine Isaguirre, Megan R. Gendjar, Jason Cooper, Sawyer F. Barton, Kim P. Nguyen, Ryan D. Sheldon, Connie M. Krawczyk, Nicholas O. Burton

Institution: Van Andel Institute

Language: English

Topic: Polyamine Metabolism and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Office of Extramural Research, National Institutes of Health

Awards: G1080838997, IDENTIFYING MICROBIAL MECHANISMS THAT REGULATE ANIMAL INSULIN SIGNALING, G7903129812, G8279163776

OpenAlex ID: W4416717492

FWCI: 1.26

Cites: 68

Cited by: 5

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