Work

The relationship between the expression and clinicopathology of long non-coding RNA in older adults with non-small cell lung cancer

Year: 2025

Type: article

Abstract: This study investigates the expression of long non-coding RNA (lncRNA) in older adults with non-small cell lung cancer (NSCLC) and its relationship with clinicopathology. Tumor and adjacent normal tissues were collected from 97 elderly NSCLC patients. The differentiation antagonizing non-protein coding RNA (DANCR) expression was analyzed using microarray and validated by quantitative reverse transcription polymerase chain reaction. Bioinformatic methods identified DANCR-associated pathways. Clinicopathological correlations were assessed using logistic regression, and survival analysis was performed based on 24-month follow-up data. DANCR was significantly upregulated in tumor tissues (P < .005) and associated with larger tumor diameter, advanced stage, and poor differentiation (P < .05). Patients with low DANCR expression exhibited longer overall survival and progression-free survival (P < .05). lncRNAs are differently expressed and potentially play a regulatory role in the occurrence and development of NSCLC in older adults. Candidate lncRNA DANCR is highly expressed in older adults with NSCLC, which closely relates to clinical pathology and can contribute to progression-free survival and overall survival time prediction.

Source: Medicine

DOI: 10.1097/md.0000000000045947

Authors: Huimin Liu, Zhiqing Feng, Qi Quan, Shu Yang, Qi Chen

Institutions: First Affiliated Hospital of Guangdong Pharmaceutical University, Sun Yat-sen University Cancer Center

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950