Work

Immune-inflammation markers are related to hormone levels in polycystic ovary syndrome: a case-control study

Year: 2025

Type: article

Abstract: BACKGROUND: We aimed to evaluate the relationships between the pan immune-inflammation value (PIV), the systemic immune-inflammation index (SII), and hormonal levels in patients with polycystic ovary syndrome (PCOS). METHODS: ), prolactin, free and total testosterone, estradiol, luteinizing hormone (LH), 17-OH-progesterone, follicle-stimulating hormone (FSH), and 11-deoxycorticosterone were examined. Hematological indices, SII and PIV, were calculated. Receiver operating characteristic (ROC) analysis showed the diagnostic potential of the research parameters. RESULTS: levels (p = 0.006, p = 0.003, p = 0.037, p = 0.042, respectively). A statistically significant and positive correlation was also observed between PIV and free testosterone levels (p = 0.008). We found that a baseline serum SII > 520.0 and PIV > 262.4 were associated with PCOS with 65% specificity and 61% sensitivity for the SII (area under the curve [AUC], 0.669; 95% CI 0.584-0.755; p < 0.001) and 58% specificity and 60% sensitivity for the PIV ([AUC], 0.642; 95% CI 0.555-0.729; p = 0.002). CONCLUSIONS: Monitoring SII and PIV may assist clinicians in evaluating inflammation and treatment needs in patients with PCOS. CLINICAL TRIAL NUMBER: Not applicable.

Source: BMC Endocrine Disorders

DOI: 10.1186/s12902-025-02094-w

Authors: Isil Cakir, Nuri Çakir

Institution: Kayseri Eğitim ve Araştırma Hastanesi

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190