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SENP5 acts as a downstream target of androgen receptor and contributes to prostate cancer growth

Year: 2025

Type: article

Abstract: The androgen receptor (AR) signaling pathway plays an important role in prostate cancer (PCa) progression. In the present study, a significant co-expression was found between SENPs and AR. In addition, SENP5 was obviously negatively correlated with overall survival and disease-free survival in patients with PCa. Moreover, SENP5 silencing markedly inhibited the proliferation of PCa cells. Chromatin immunoprecipitation quantitative PCR assays further confirmed that AR could transcriptionally activate SENP5 expression. In summary, the present results suggested that SENP5 acts as a downstream target of AR and contributes to PCa growth, the underlying molecular mechanism of which needs further investigation.

Source: Oncology Letters

DOI: 10.3892/ol.2025.15404

Authors: Ximin Chen, Xubo Gong, Jingcheng Zhang, Weiwei Liu

Institutions: Chengdu Medical College, Second Affiliated Hospital of Zhejiang University, Zhejiang University

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Zhejiang University