Work

Nutritional Modulation of the Gut Microbiome in Relation to Prenatal Lead-Induced Neurotoxicity: A Review

Year: 2025

Type: review

Abstract: Prenatal exposure to lead (Pb) is a well-established risk factor for adverse neurodevelopmental outcomes. Despite its recognized risks, prenatal Pb exposure remains largely unregulated and poorly addressed in public health policy. Evidence suggests that the gut microbiome may mediate the neurotoxic effects of metals, offering a potential target for intervention. Here we discuss how nutritional factors, particularly those influencing the gut microbiome, may reduce the neurotoxicity of prenatal Pb exposure.

Source: Nutrients

DOI: 10.3390/nu17233700

Authors: Shoshannah Eggers, Kiran P. Nagdeo, Kshitij Sachdev, Delaney Robinson, Andrea L. Deierlein, Jamil M. Lane, Chris Gennings, Ryan W. Walker, Linda Snetselaar, Nichole Nidey, Elizabeth E. O’Neal, Vishal Midya

Institutions: University of Iowa, New York University, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499

Funders: National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G2405278711, G8163767318, Environmental Health Sciences Research Center, Early life metal exposure, the gut microbiome, and neurodevelopment in childhood

OpenAlex ID: W4416723977

FWCI:

Cites: 64

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