Work

New insights into radiolabelled siderophores for molecular imaging of bacterial infections

Year: 2025

Type: article

Abstract: This perspective article aims to provide an update on current trends in the research of radiolabelled siderophores for molecular imaging of bacterial infections. It begins by explaining the importance of developing novel diagnostic tools for infections and addresses the limitations of contemporary methods, including molecular imaging. The discussion then shifts to compounds currently being studied for nuclear imaging, with a focus on radiolabelled siderophores and recent advances in their development. It also provides the latest insights into the structures of siderophores, their utilisation by bacteria and their role in bacterial metabolism, as well as potential for labelling with various radioisotopes. Additionally, it presents the use of radiolabelled siderophores, both naturally occurring and artificial siderophore derivates, for imaging of various bacterial infections.

Source: npj Imaging

DOI: 10.1038/s44303-025-00126-7

Authors: Katerina Dvorakova Bendova, Kristyna Krasulova, Barbora Neuzilova, Marian Hajduch, Milos Petrik

Institutions: Institute of Molecular and Translational Medicine, Palacký University Olomouc, University Hospital Olomouc

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790