Work

β-Substituted Styrenes in Heteroaryl-Directed Hydroalkylative Cross-Couplings: Regio-, Diastereo-, and Enantioselective Formation of β-Stereogenic Tertiary Alcohols

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Under iridium-catalyzed conditions, 2-azaaryl-substituted secondary alcohols undergo C(sp 3 )–H addition reactions to β-substituted styrenes to provide alkylated tertiary alcohols. The processes occur with high regio-, diastereo-, and enantioselectivity and offer unusual examples of 1,2-disubstituted styrenes engaging in α-selective and stereocontrolled C–H addition reactions.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c17840

Authors: Wenbin Mao, Craig M. Robertson, John F. Bower

Institution: University of Liverpool

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Deutsche Forschungsgemeinschaft, European Research Council