Development of the 5-Nitrosalicaldehyde Arylhydrazones as Anticancer (MCF-7 and HCT116) Agents Targeting Inhibition of VEGFR-2 and Cytokines (IL-6 and TNF-α)
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide A pseudoring replacement strategy has been employed to develop the 3-halogeno-substituted 5-nitrosalicylaldehyde arylhydrazones as potential antibreast (MCF-7) and anticolorectal (HCT116) cancer agents. The mechanism of action of the test compounds was investigated through cell cycle analysis, annexin staining (apoptosis induction), and enzymatic inhibition assays targeting vascular endothelial growth factor receptor-2 (VEGFR-2) kinase and cytokine (IL-6 and TNF-α) inhibition, including comprehensive in silico studies.
Source: ACS Omega
Institutions: University of South Africa, Al-Azhar University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Funder: National Research Foundation
Award: G7628009016
OpenAlex ID: W4416724675