Year: 2025
Type: article
Abstract: The concept of "mixed pain" simultaneously highlights the benefit of integration of emerging advances in basic science (in particular, physiologic mechanisms) with advances in clinical care (symptomatology and diagnosis), and highlights some current prevailing challenges for both. This dichotomy is reflected in the very definitions or descriptions of mixed pain as a type of pain that manifests with symptoms that include those indicative of both nociceptive pain (viz., pain arising from tissue damage) and of neuropathic pain (i.e., pain arising from nerve damage), and possibly including other types of pain. The dichotomy also underscores the difficulty that is encountered treating such condition(s). Pharmacologic approaches are often accompanied by a variety of complementary non-pharmacologic approaches such as physical therapy, cognitive-behavioral therapy, immune and nutritional boosters, and a host of other modalities aimed at the attenuation of pain. This Perspective reviews the centrally-acting analgesics that have mixed mechanisms of analgesic action.
Source: Frontiers in Medicine
Author: Robert B. Raffa
Institution: Temple University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416729228