Ultrasound urodynamic studies (US-UDS): noninvasive estimation of detrusor pressure through ultrasound
Year: 2025
Type: article
Abstract: Objective. Urodynamic studies (UDSs) are vital for evaluating bladder function but require invasive catheterization to measure detrusor pressure ( P det ). Our purpose is to report on technical developments toward a noninvasive and accurate estimation of P det through ultrasound (US), a technique we refer to as US-UDS. Approach. The proposed US-UDS technique produces an estimate of P det by using US to induce and track elastic waves that propagate within and around the bladder wall. Key components of the US-UDS processing include: an US sequence with dense time sampling; an empirical correction accounting for deviation from a Lamb wave dispersion model; and constrained optimization for P det estimation. US-UDS analysis for estimation of P det was applied to 533 distinct data points collected from 3 human subjects undergoing concurrent UDS. Concordance analysis was used to evaluate agreement between US-UDS and UDS measures of P det while response operator characteristic analysis was used to evaluate US-UDS for detection of detrusor activity (parameterized as UDS P det >15 cmH 2 O). Main results. US-UDS was able estimate P det within 10 cmH 2 O and 5 cmH 2 O of UDS measurements with coverage probabilities of 95.7% and 68.8% respectively. Furthermore, US-UDS was able to detect UDS P det measurements greater than 15 cmH 2 O with a sensitivities and specificities of 0.99 and 0.83 using a fixed threshold (>15 cmH 2 O for US-UDS) and 1.0 and 0.93 for an optimized threshold (> 11.08 cmH 2 O for US-UDS). Significance. Our results show that the technical developments of US-UDS put forth in this work are able produce accurate and useful estimates of P det as compared to traditional UDS. Although additional research with a large number of subjects is needed to fully characterize the clinical utility of US-UDS, the developments and results from this work demonstrate that clinically useful non-invasive measurements of P det are feasible from US measurements.
Source: Physics in Medicine and Biology
Institution: Mayo Clinic
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,325
OpenAlex ID: W4416729330