Work

Efficacy of lung surfactant combined with budesonide in improving bronchopulmonary dysplasia and growth of very low birth weight infants

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background There is few treatments for bronchopulmonary dysplasia (BPD), and systemic glucocorticoid therapy has serious side effects. Methods Low birth weight infants were classified randomly into control group administered with pulmonary surfactant (200 mg/kg) and intervention group administered with pulmonary surfactant (200 mg/kg) and budesonide suspension (0.25 mg/kg) to explore the efficacy of combination of pulmonary surfactant and budesonide suspension is better than that of pulmonary surfactant alone. Results The incidence of bronchopulmonary dysplasia was significantly lower in the intervention group (45%) compared to the control group (64%). Additionally, the duration of invasive ventilator use was significantly shorter in the intervention group (66.39 ± 37.09 h) than in the control group (82.05 ± 54.55 h); and the infants from the intervention group had a significantly shorter supplemental oxygen time, with the intervention group at 775.32 ± 396.06 h and the control group at 844.01 ± 414.18 h. Comparison of the basic conditions of the two groups of children showed no statistically significant differences in maternal medical history, gestational age, birth weight, sex, whether hormones were used prenatally, and delivery method ( P > 0.05). There was no difference in the incidence of complications, such as neonatal infection, intracranial hemorrhage, necrotizing enterocolitis, and retinopathy between the two groups. Conclusion Combination of pulmonary surfactant with budesonide suspension can significantly decrease the incidence of bronchopulmonary dysplasia in very low birth weight infants, reduce the duration of invasive mechanical ventilation, and promote earlier weaning from oxygen supplement. Clinical Trial Registration Effect of budesonide combined with pulmonary surfactant on lung development in very low birth weight infants, ChiCTR2400086677, https://www.chictr.org.cn/showproj.html?proj=233373 .

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1686811

Authors: Yu Zhang, Ming Liu, Yue Li, Di Chi, Jinpu Zhang, Yunfeng Zhang

Institutions: Jilin University, Second Affiliated Hospital of Jilin University

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801