Case Report: CytoSorb hemoadsorption as an adjunctive therapy in critically ill pregnant women with COVID-19 and acute kidney injury—a case series
Year: 2025
Type: article
Study design: Case Report
Abstract: Purpose: Critically ill pregnant women with COVID-19 are at high risk for acute kidney injury (AKI) and a hyperinflammatory state, contributing to multiorgan failure. This case series describes the adjunctive use of CytoSorb hemoadsorption therapy in this population. Methods: We present four critically ill pregnant women with COVID-19 pneumonia, AKI, and clinical signs of hyperinflammation. All patients were admitted to the intensive care unit (ICU) and received CytoSorb therapy, integrated with continuous renal replacement therapy (CRRT) or used as a standalone treatment. We analyzed clinical parameters (SOFA score, vasopressor requirement, PaO₂/FiO₂ ratio) and inflammatory biomarkers (C-reactive protein, ferritin) before and after CytoSorb initiation. Results: Following CytoSorb therapy, all four patients showed clinical improvement, evidenced by a reduction in SOFA scores, decreased vasopressor needs, and improved oxygenation. A concomitant decrease in inflammatory markers was also observed. All four patients survived and were discharged from the hospital in stable condition after an average ICU stay. Conclusion: In this small case series, adjunctive CytoSorb hemoadsorption was associated with rapid clinical stabilization and recovery in critically ill pregnant women with COVID-19, AKI, and hyperinflammation. These promising results warrant further investigation in controlled studies to confirm the efficacy and safety of this approach.
Source: Frontiers in Medicine
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416730312