Diagnosing acute appendicitis in children with neutrophil–lymphocyte ratio: a cross-sectional study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Diagnosing acute appendicitis (AA) in children can be challenging due to atypical symptoms and the difficulty in obtaining a comprehensive history. This study aimed to evaluate the value of the neutrophil-to-lymphocyte ratio (NLR) in diagnosing AA in the pediatric population. Methods This retrospective cross-sectional study involved 200 pediatric patients aged between 0 and 14 years of both sexes, who underwent appendectomy for suspected acute appendicitis. Data of patients were retrieved from the hospital's patient administration system database. We categorized patients into three surgical groups: Group 1, appendectomy + normal appendix ( n = 32); Group 2, appendectomy + acute appendicitis (AA) ( n = 133); and Group 3, appendectomy + perforated appendicitis ( n = 35). Results White blood cell (WBC) count, neutrophil count, and NLR were significantly higher in the acute appendicitis and complicated appendicitis groups than those in the normal appendix group and in the complicated appendicitis group than those in the acute appendicitis group. In multivariate regression, WBC count and NLR were associated with AA ( P ≤ 0.001). NLR was associated with complicated appendicitis ( P = 0.012). It was also significantly associated with AA and complicated appendicitis at cutoff values >1.7 and >3.5, respectively, with 74% and 68.57% sensitivity and 69% and 56.98% specificity. Conclusions NLR is a potentially useful adjunctive and cost-effective diagnostic marker for AA and complicated appendicitis in the pediatric population.
Source: Frontiers in Pediatrics
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4416730745