A case report of giant smooth endoplasmic reticulum clusters in oocytes, post-ICSI: Successful outcome leading to live birth.
Year: 2025
Type: article
Study design: Case Report
Abstract: This particular case study examines the association between oocyte morphology and assisted reproductive technology (ART), particularly, the smooth endoplasmic reticulum clusters (sERCs). It describes an extraordinary case in which 80% of the mature oocytes had giant sERCs, which raised concerns about the oocyte quality and the resultant embryonic development and clinical prognosis It concerned a patient who underwent intracytoplasmic sperm injection (ICSI). Two embryos, derived from oocytes with sERCs, were transferred on day 3 following ICSI and sERCs became the focus. The results covered the entire continuum of fertilization, embryonic maturation, and clinical outcomes, the endpoint of which was a successful live birth. Such results demonstrate the complex background between the oocyte dysmorphia and reproductive performance, still, in ART, it is possible that considerable dysmorphia is not necessarily a negative prognostic factor. Further studies are needed to address the oocyte dysmorphia and ART's changes.
Authors: Yuhua Zhang, Kunkun Liu, Dan Wang, Pingping Sun, Jinguang Wang, Wenjie Zhao
Institution: Weifang People's Hospital
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416737982
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