Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk
Year: 2025
Type: article
Abstract: Integrin αvβ3, a key member of the integrin family, plays a crucial role in cell localization, mobilization, and signal transduction through collaborating with extracellular proteins. Its unique expression and activation in tumor cells and rapidly dividing endothelial cells suggest its potential role in cancer cell growth and metastasis, making it a promising therapeutic target. In genomic pathways, estrogen binds to its receptors to form transcription complexes that bind to the promoters of steroid hormone-receptive genes. Conversely, G protein-coupled estrogen receptor 1 (GPER) and integrin αvβ3 have been shown to play oles in non-genomic actions that contribute to estrogen-induced cancer growth. The molecular mechanisms of these non-genomic functions involve signal transduction via focal activated kinase (FAK), mitogen-activated protein kinase (ERK1/2), and phosphatidylinositol 3-kinase (PI3K), as well as the differential expression of multiple genes associated with various cellular processes. As a hormone receptor, integrin αvβ3, collaborating with ER-α and GPER, exhibits a wide range of cellular effects relevant to cancer biology.
Source: Cells
Authors: Kuan Wang, Zi-Lin Li, Lin-Yi Huang, Chih-Jung Yao, Dana R. Crawford, Chih-Yang Wang, Ju-Ku Mo, Ya-Jung Shih, Hung-Yun Lin, Jacqueline Whang-Peng
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,258
Awards: Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation, To Define the Attributes of a Novel Theranostic Nanoparticle Dl-N2 to Targeted Integrin Αvβ3 Network in Cholangiocarcinoma( III ), Pathogenic Role of Integrin Αvβ3—Pd-L1—Β-Catenin Axis and Its Therapeutic Strategies in Colorectal Cancer, To Enhance Theranostic Effect of Dl-N2-Payload with Anti-Ceacam6 Antibodies in Cholangiocarcinoma in Vitro and in Xenograft Models( III ), Study the Combination Effects of Selenium Yeast and Fish Oil to Synergistically Regulate the Glycogen Synthase Kinase-3 (Gsk-3)/Tbet/Pd-1 Axis of T Cells for Enhanced Anti-Tumor Immunity, G842824224
OpenAlex ID: W4416738504