Work

Single mutation tunes IRF4 function and mediates B cell character to ameliorate murine lupus

Year: 2025

Type: article

Abstract: mutation reinforced phosphorylated STAT3 binding and therefore enhanced B7-H1 transcription. These results indicate the specific role of IRF4 in B cells and lupus, providing a potential therapeutic target to combating SLE.

Source: iScience

DOI: 10.1016/j.isci.2025.113884

Authors: Ze Xiu Xiao, Rongzhen Liang, Xiaojiang Hu, Changyuan Huang, Jia Nie, Chichu Xie, Julie Wang, Qiannan Fang, Xiaoli Fan, Nancy Olsen, Li Zhou, Bin Li, Song Guo Zheng

Institutions: Sun Yat-sen University, Shanghai Jiao Tong University, Third Affiliated Hospital of Sun Yat-sen University, Guangdong Medical College, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Shanghai Institute of Immunology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Pennsylvania State University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1604137293, G303567496, G486495788, G4951763179, G629779471, G8241826287

OpenAlex ID: W4416738665

FWCI: 0.643

Cites: 89

Cited by: 1

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