Supplementary Figures 1-7 from ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Year: 2025
Type: supplementary-materials
Abstract: S1. Identification of novel ATM-interactors using BioID. S2.NIPBL, PDS5A, and PDS5B are required for chromosomal stability and viability after IR. S3. Mutation of Fok1 nuclease domain blocks DSB formation. S4. Low dose IR causes suppression of DNA replication within the vicinity of the DSBs. S5. Fok1-induced DSBs do not result in a decrease in nuclear DNA replication. S6. Repression of DNA replication around DSBs is dependent on ATM and not ATR or DNAPK. S7. ATM phosphorylation of cohesin is required for repression of DNA replication within the vicinity of a DSB.
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4416739904