Prognostic significance of CD44s expression in oral squamous cell carcinoma: An immuno-histo-chemical analysis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Oral squamous cell carcinoma (OSCC) is a common malignancy with a poor prognosis, highlighting the need for reliable molecular biomarkers. CD44s, a cell adhesion molecule, has been implicated in tumor progression, but its prognostic role in OSCC is unclear. This retrospective study evaluated CD44s expression in 50 OSCC cases using immunohistochemistry and an immunoreactive scoring system. High CD44s expression significantly correlated with advanced stage, lymph node metastasis and poor histological grade. CD44s overexpression may serve as a prognostic biomarker to identify high-risk OSCC patients requiring aggressive therapy.
Source: Bioinformation
Authors: Hershita Singh, Sandeep Sidhu, Arun Bhardwaj, Arpit Sharma, Mamta Sharma, Shivendra Rana
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4416740055
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