Esophageal cancer staging in Malawi: the feasibility of chest radiography and abdominal ultrasound for initial evaluation
Year: 2025
Type: article
Abstract: BACKGROUND: Esophageal cancer (EC) is the third leading cause of cancer-related morbidity and mortality in Malawi. Given limited imaging capacity and high costs, staging is not routinely performed. One proposed staging algorithm is to first evaluate for metastatic disease using low-cost chest radiography (CXR) and abdominal ultrasound (US) followed by confirmatory computerized tomography (CT) of the chest and abdomen if no metastases identified on initial screening. The feasibility of this approach is unknown for EC in sub–Saharan Africa and was studied in the context of a larger prospective observational cohort study of EC in Malawi. METHODS: From 2021 to 2022, EC patients at Kamuzu Central Hospital in Lilongwe, Malawi enrolled in the Treatment Outcomes of Esophageal Cancer in Malawi (TOEC-M) study were recruited. Participants were scheduled for a CXR, US, and CT scan as part of this sub-study. Participant characteristics, completion rates, imaging findings, and barriers to completion were documented. For participants undergoing all three imaging studies, sensitivity and specificity were calculated. RESULTS: Of 150 patients in TOEC-M, 67 (44.7%) enrolled in this sub-study. Mean age was 55.4 years and 50.8% were males. The majority had mid-esophageal (38 [56.7%]) squamous cell carcinomas (54 [80.6%]). CXR was completed in 54 (80.6%) study participants, US in 43 (64.2%), CT chest in 29 (43.3%), and CT abdomen in 24 (35.8%). Sixteen (23.9%) completed all studies and 4 (6.0%) did not undergo any imaging. Of the 63 patients that were imaged, metastatic disease was identified in 18 (28.6%) by any modality. Positive findings were identified on 3 (5.6%) CXRs, 4 (9.3%) US, and 18 (62.1%) CTs, most frequently liver masses followed by lung nodules and adenopathy. Barriers to imaging completion included participant functional status and scanner availability. CONCLUSIONS: As access to EC treatment modalities expands, feasible and accurate staging will become increasingly important to guide clinical management. Our results suggest that CXR and US may serve as useful initial tools for assessing metastatic disease. In patients not medically fit for oncologic treatment, positive findings on CXR and US may allow CT to be deferred. Barriers to implementation of a pragmatic stepwise staging algorithm identified in this study can inform future research and care for patients with EC in similar resource-limited settings.
Source: BMC Gastroenterology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
Funders: National Science Foundation, Howard Hughes Medical Institute, National Aeronautics and Space Administration, Bill and Melinda Gates Foundation, Hirshberg Foundation for Pancreatic Cancer Research, Amway Corporation, Natural Science Foundation of Shanghai, Fondation Brain Canada, Wellcome Trust, Cyrus Tang Foundation, Ministerio de Ciencia, Innovación y Universidades, R. Howard Webster Foundation, ACT Government, Science and Technology Department of Xinjiang Uygur Autonomous Region, Health Commission of Hebei Province, Health Commission of Heilongjiang Province, National Institute for Health and Care Research, British Academy, Deutsche Forschungsgemeinschaft, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Canada Research Chairs, National Natural Science Foundation of China, ZonMw, Universidad Nacional de Colombia, Chiang Mai University, Ministerio de Economía y Competitividad, Gemeinnützige Hertie-Stiftung, Lundbeckfonden, National Research Foundation of Korea, Department of Science and Technology of Sichuan Province, National Taiwan University, Natural Science Foundation of Shandong Province, King Khalid University, Northern Borders University, Majmaah University, Heilongjiang University of Chinese Medicine, Novo Nordisk Fonden, Shaoxing Bureau of Science and Technology, Department of Science and Technology of Jilin Province, Major Program of National Fund of Philosophy and Social Science of China, Zhuzhou Science and Technology Bureau, Natural Science Foundation of Xinjiang, Luzhou Science and Technology Bureau, Ministero dell'Università e della Ricerca, National Institutes of Health, U.S. Geological Survey, Institute of Education Sciences, Wu Jieping Medical Foundation, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Engineering and Physical Sciences Research Council, Fundação para a Ciência e a Tecnologia, Innovate UK, National Key Research and Development Program of China, Zhejiang Traditional Chinese Medicine Administration, Fundamental Research Funds for the Central Universities, National Science Fund for Distinguished Young Scholars, Tianjin Science and Technology Program, National Heart, Lung, and Blood Institute, Fogarty International Center, National Center for Research Resources, National Center for Advancing Translational Sciences, Medical Science and Technology Project of Zhejiang Province, H2020 European Research Council
OpenAlex ID: W4416744029