Work

Flax lignan-fortified nanoemulsions potentiate the conversion of α-linolenic acid to n-3 LCPUFAs: cumulative metabolic patterns in non-fasting mice

Year: 2025

Type: article

Abstract: metabolic studies and HepG2 cell experiments indicated that the structural characteristics of flax lignans might determine their material basis of intestinal transport and hepatic metabolism, thereby modulating ALA absorption, transport, and conversion, with the characteristic metabolites SDG and enterodiol (ENL) further promoting downstream ALA-derived products (C20:4n-3, 48.6% or C20:3n-3, 48.1%), highlighting their regulatory roles. This study provides a theoretical foundation for developing functional lipid delivery systems based on lignan structural features and nutritional intervention strategies aimed at enhancing ALA metabolic conversion.

Source: Food & Function

DOI: 10.1039/d5fo03469h