Work

Early postoperative acute kidney injury prediction in patients with acute type A aortic dissection

Year: 2025

Type: article

Abstract: Acute kidney injury (AKI) is a frequent and serious complication following surgery for acute type A aortic dissection (AAD), often leading to delayed treatment and poor outcomes. This multicenter study developed and validated a predictive nomogram for early postoperative AKI in 1,211 AAD patients. Using logistic regression, independent risk factors were identified: age, hypertension, preoperative shock, and cardiopulmonary bypass time. The model demonstrated robust performance, with area under the curve values of 0.749 and 0.753 in internal and external validation cohorts, respectively. Decision curve analysis confirmed the nomogram's clinical utility, providing superior net benefit over postoperative creatinine levels when the predicted AKI risk exceeds 50%. This tool enables early identification of high-risk patients, facilitating timely interventions to improve perioperative management and outcomes in this critical surgical population.

Source: iScience

DOI: 10.1016/j.isci.2025.114222

Authors: Ling Chen, Yichao Pan, Huaijian Zhang, Huihui Xue, Zhihuang Qiu, Liangwan Chen

Institutions: Fujian Medical University, Union Hospital, Xiamen University, First Affiliated Hospital of Xiamen University

Language: English

Topic: Aortic Disease and Treatment Approaches

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240