Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: We aimed to provide real-world insights into the management of non-small cell lung cancer stage III (NSCLC-SIII) in Spain. Methods: The GOECP-SEOR group conducted an observational, retrospective, multicenter study in which data from patients diagnosed with NSCLC-SIII treated in Spanish radiotherapy departments (RTDs) were collected. Results: A total of 1505 NSCLC-SIII patients from 35 RTDs from 2018 to 2021 were recruited. A total of 871 patients (57.9%) received concurrent chemoradiotherapy (cCRT), and 390 patients (25.91%) received maintenance durvalumab. The immunotherapy (IT) was well tolerated, with Common Terminology Criteria for Adverse Events (CTCAE) Grade 0–2 toxicity observed in 85% of the patients (295 patients). The median overall survival (OS) was 26 months (95% CI 9.4-Not Reached NR). There was a statistically significant difference when patients were stratified by IT, with a median OS of 40 months (95% CI 22.1-NR) in the IT maintenance cohort compared with 19.4 months (95% CI 7.1–58.1) in the non-IT cohort. Differences were also noted in progression-free survival (PFS), with a median PFS of 20.8 months (95% CI 9.6-NR) in the IT cohort versus 8.4 months (95% CI 3.1–25.1) in the non-IT cohort. These differences remained significant according to the multivariate model (OS: HR 0.45 [95% CI 0.36–0.56], p < 0.001; PFS: HR 0.5 [95% CI 0.42–0.59], p < 0.001). Conclusions: The management of NSCLC-SIII patients can vary, leading to differences in treatment outcomes. The treatment of lung cancer in NSCLC-SIII patients in RTDs across Spain aligns with international guidelines and expert recommendations.
Source: Cancers
Authors: Paloma Sosa-Fajardo, Margarita Martín-Martín, Javier Luna-Tirado, José Luis López-Guerra, Elías Gomis-Sellés, Miriam López-Mata, Germán Valtueña-Peydró, Marina Santos-Rodríguez, Ana-María Álvarez-González, Guillermo Potdevin-Stein, Paula Martín-Barrientos, Andrea Kannemann, Nuria Farré-Bernadó, Elisabet González-Portillo, Aurea Manso-Lema, Marta Rodríguez-Roldán, María-Ángeles González-Ruiz, Amadeo Wals-Zurita, Nuria-Azahara Linares-Mesa, Sara Garduño-Sánchez, Patricia Barrionuevo-Castillo, Beatriz Moreno-Fuentes, Maximiliano Martos-Alcalde, Paula Simón-Silva, Mariana-Teresa Peña-Perea, Manuel-Luis Blanco-Villar, Victoria Vera-Barragán, Abrahams Ocanto-Martínez, María Mateos-Domínguez, Carmen Vallejo-Ocaña, Raúl Hernanz-Lucas, José-Enrique Castro-Gómez, Marina Peña-Huertas, Víctor Duque-Santana, José Zapatero-Ortuño, Celia García-Torres, Patricia Valencia-Nieto, Patricia Diezhandino-García, Clara Eito-Valdovinos, Alicia Olarte-García, Luis-Leonardo Guerrero-Gómez, Sofía Sánchez-García, Andrea Bobo-Jaureguizar, Amalia Sotoca-Ruiz, Beatriz Vázquez-Barreiro, Guillermo Cameselle-Gallego, Sonia Flamarique-Andueza, Mikel Rico-Oses, Marcos Guijarro-Verdu, Miguel Montijano-Linde, Laura Guzmán-Gómez, Ana-Belén Bezares-Alarcón, Cristina Cigarral-García, Paloma Moreno-Ceano, Javier Serrano-Andreu, Mauricio Murcia-Mejía, María Pagola-Divassón, Francesc Casas-Duran, Piedad Almendros-Blanco, Sara Pedraza-Fernández, José-Antonio González-Ferreira, Pino Alcántara, Felipe Couñago
Institutions: Hospital Universitario Virgen del Rocío, Hospital Universitario Ramón y Cajal, Hospital Universitario Fundación Jiménez Díaz, Hospital Clínico Universitario Lozano Blesa, Hospital General Universitario Gregorio Marañón, Hospital Universitario de Gran Canaria Doctor Negrín, Fundación Valle del Lili, Hospital de Sant Pau, Hospital Universitario La Paz, Hospital Universitario Virgen Macarena, Hospital Juan Ramón Jiménez, Complejo Hospitalario de Jaén, Complejo Hospitalario Torrecárdenas, Hospital Universitario de Torrejón, Complejo Hospitalario de Ourense, Hospital Universitario Quirónsalud Madrid, IDCQ Hospitales y Sanidad, S.L.U., Universidad Europea de Madrid, Hospital Universitario Rey Juan Carlos, Hospital Clínico Universitario de Valladolid, Clinic IMQ Zorrotzaurre, Hospital La Luz, Hospital Ruber Internacional, Clinica Universidad de Navarra, GenesisCare, Complejo Hospitalario de Salamanca, Hospital Universitari Sant Joan de Reus, Hospital Clínic de Barcelona, Hospital General Universitario De Valencia, Hospital Universitario 12 De Octubre, Hospital Clínico San Carlos
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Funder: AstraZeneca
OpenAlex ID: W4416746746