Management of endothelial dysfunction in septic shock: role of albumin administration
Year: 2025
Type: article
Abstract: Sepsis is a significant global health issue, with high morbidity, mortality, and economic burden. Its definition has evolved, with the latest Sepsis-3 criteria emphasizing life-threatening organ dysfunction due to a dysregulated host response. Endothelial dysfunction plays a critical role in sepsis pathogenesis, characterized by increased permeability and inflammatory responses. Human serum albumin, the most abundant protein in the bloodstream, is essential for maintaining oncotic pressure and endothelial integrity. This narrative review provides an overview of endothelial changes during sepsis and their impact on organ damage. We also explore the role of albumin administration in managing endothelial dysfunction in sepsis and discuss the available preclinical and clinical evidence.
Source: Journal of Intensive Care
Institutions: Trinity College Dublin, St. James's Hospital, Hospital Universitari Joan XXIII de Tarragona, University of Copenhagen, Herlev Hospital, Copenhagen University Hospital, Gentofte Hospital, Linköping University, Karolinska University Hospital, Hebrew University of Jerusalem, Maccabi Healthcare Services, University of Cambridge, Addenbrooke's Hospital, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille, Hôpital Nord
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,577
Funders: Grifols, Medical Research Council
OpenAlex ID: W4416748164