Work

Ethnic differences in risk of renal disease progression amongst young-onset type 2 diabetes in New Zealand

Year: 2025

Type: article

Abstract: AimMāori and Pacific adults in New Zealand (NZ) with type 2 diabetes are at high risk of Diabetic Kidney Disease (DKD).This study assessed whether the same was true in young-onset type 2 diabetes. MethodsWe conducted a secondary analysis of young adults 18-40 years enrolled in a (1994-2018) NZ primary care cohort.DKD risk was classified as minimal or elevated using Urine Albumin-Creatinine Ratio (UACR) and Estimated Glomerular Filtration Rate (eGFR), with hyperfiltration (eGFR≥120mL/min/1.73m²)considered an early marker.Logistic regression identified predictors of elevated DKD risk. ResultsAmong 2,184 participants (46% Pacific people, 31% Māori, 23% NZ European: 54% female, mean age 33.9±4.9years, mean BMI 38.0±8.7 kg/m 2 , diabetes duration 1.7 years), elevated DKD risk was more common in Pacific People (37.4%) and Māori (33.5%) than NZE (23.3%; p<0.001) with adjusted odds ratio (vs NZE) of 1.96 (95% CI: 1.50-2.57)and 1.41 (1.06-1.87)respectively.Māori had less risk than Pasifika (odds ratio 0.72 (0.58-0.89)).Independent predictors of DKD risk included ethnicity, triglyceride-HDL ratio, systolic blood pressure, antihypertensive use, and HbA 1c : BMI was not significant. ConclusionsPacific and Māori with young-onset type 2 diabetes face a disproportionately higher DKD risk.6

Source: Diabetes Research and Clinical Practice

DOI: 10.1016/j.diabres.2025.113018