Adhesion of Immunoglobulins to Band3 Promotes Increased Erythrocyte Sedimentation Rate in Multiple Myeloma
Year: 2025
Type: article
Abstract: Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the loss of sialic acid coverage. Immunoglobulins in plasma adhere to RBC membrane Band3 extracellularly exposed peptides through intermolecular interactions. The reduction of sialic acid causes a weakening of the RBC membrane negative charge barrier and the adhesion of immunoglobulins further destabilises the suspension of RBCs, resulting in a rapid addition of ESR to multiple myeloma.
Source: Cell Proliferation
DOI: 10.1111/cpr.70149
Institutions: MetroHealth, Harbin Medical University, First Affiliated Hospital of Harbin Medical University, Case Western Reserve University, Shanxi Medical University, Second Hospital of Shanxi Medical University, First Hospital of Shanxi Medical University, Shanxi Province Hospital of Traditional Chinese Medicine, Qingdao University, Yuhuangding Hospital, Shanghai Jiao Tong University, University of Cambridge, Fujian Medical University, Fujian Provincial Hospital, Fuzhou University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,680
OpenAlex ID: W4416755104