Work

Lower lobe mucus plug distribution and future respiratory exacerbations in tobacco-exposed individuals with and without COPD

Year: 2025

Type: article

Abstract: Extract Mucus plugs (MPs) on chest computed tomography (CT) are highly prevalent and are associated with increased respiratory symptoms[1], worse lung function[1], increased mortality[2] and acute exacerbations[3] among individuals with chronic obstructive pulmonary disease (COPD). Whether mucus plug distribution in the upper versus lower lobes differentially impacts future respiratory exacerbations (REs), both within established COPD and among non-obstructed tobacco-exposed individuals, has been incompletely explored.

Source: European Respiratory Journal

DOI: 10.1183/13993003.00523-2025

Authors: Emily S. Wan, Ruchita Borgaonkar, Sofia Mettler, Pietro Nardelli, Monica Iturrioz-Campo, Padma P. Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Scott Grumley, Andrew Yen, Sushilkumar Sonavane, Wei Wang, Michael H. Cho, Raul San José Estépar, Alejandro A. Diaz

Institutions: Brigham and Women's Hospital, VA Boston Healthcare System, University of Alabama at Birmingham, University of California San Diego, Mayo Clinic in Florida

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Heart, Lung, and Blood Institute, NHLBI Division of Intramural Research

Awards: G117627397, G1199835846, G2457154707, G4659381181, G5605088617, (2 of 2) Genetic Epidemiology of COPD, G676822413, (1 of 2) Genetic Epidemiology of COPD, Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in Smokers, G8419803424, Understanding airway mucus dysfunction in population-based studies, Clinical implications and Proteomics of Bronchiectasis Progression in Smokers

OpenAlex ID: W4416757159

FWCI: 0.591

Cites: 7

Cited by: 1

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