Work

Whole lung directed anti-muscarinic therapy improves small airway dysfunction in COPD patients

Year: 2025

Type: article

Abstract: Extract Small airways disease is a key feature of chronic obstructive pulmonary disease (COPD) that often precedes emphysema and is the major site of airflow limitation [1]. The prevalence of small airways dysfunction (SAD) ranges from 50–90% and correlates with COPD patient symptoms [2]. SAD is usually well-established before conventional spirometry is abnormal [3], contributes to patient quality-of-life burden [4], and disease exacerbations [5].

Source: European Respiratory Journal

DOI: 10.1183/13993003.01326-2025

Authors: Omar S. Usmani, Dimitrios Toumpanakis, Sally Meah, Vincent Mak, Martyn F. Biddiscombe

Institutions: Imperial College London, National and Kapodistrian University of Athens, University General Hospital Attikon, Imperial College Healthcare NHS Trust, Charing Cross Hospital

Language: English

Topic: Chronic Obstructive Pulmonary Disease (COPD) Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Boehringer Ingelheim