Impact and safety of remote monitoring of heart failure patients managed with the HeartLogic algorithm: the HeartLogic France Cohort Study
Year: 2025
Type: article
Abstract: Aims HeartLogic, an algorithm in implanted devices, predicts heart failure (HF) episodes via a remotely monitored index, aiding proactive congestion treatment to prevent acute decompensation. This study assessed the efficacy and safety of pre-emptive HF management using the HeartLogic index. Methods and results The HeartLogic France Cohort Study is a prospective multicentre investigation involving 310 HF patients with implanted cardioverter defibrillators enrolled from 10 French centres. The HeartLogic™ index was monitored for 12 months, and when the index reached ≥16, patients were contacted to adjust HF treatment. The primary endpoint was unscheduled hospitalization for HF. An independent blinded committee adjudicated the events. A total of 309 patients (65 ± 10 years old; 83.5% male, left ventricular ejection fraction 31 ± 9%) were included in the analysis. Ischemic cardiomyopathy was present in 61.2% (n = 189) of the patients, and 52.8% (n = 163) had a cardiac resynchronization therapy device. During follow-up, 406 alerts occurred in 158 patients (1.33 alerts/patient-year), resulting in treatment modification in 39.6% of alerts. A total of 24 unplanned HF hospitalizations occurred in 19 (6.1%) patients. Sixteen (66.7%) of those hospitalizations were preceded by a HeartLogic alert, of which 14 (87.5%) triggered a drug modification before hospitalization. Eighteen deaths (5.8%) occurred, including 10 due to cardiovascular causes. An increase in creatinine ≥30% and symptomatic hypotension were reported in two patients. Hyperkalemia and hyponatremia were not observed. Conclusion Pre-emptive HF management guided by the HeartLogic index was associated with low rates of unplanned hospitalizations and adverse events over a 12-month follow-up period. Study registration ClinicalTrials.gov, ID: NCT04619888.
Authors: Rodrigue Garcia, Daniel Gras, Jacques Mansourati, Pascal Defaye, Arnaud Bisson, Serge Boveda, Lisa Durocher, Estelle Gandjbakhch, Matthieu Gras, Jean-Pierre Gueffet, Caroline Himbert, Peggy Jacon, Pierre Khattar, Benoit Lequeux, Anthony Li, Vincent Mansourati, Damien Minois, Eloi Marijon, Bertrand Pierre, Stéphanie Ragot, Vincent Probst, Bruno Degand
Institutions: Université de Poitiers, Centre Hospitalier Universitaire de Poitiers, Hôpital privé du Confluent, Centre Hospitalier Régional Universitaire de Brest, Centre Hospitalier Universitaire de Grenoble, Université de Tours, Université d'Orléans, Centre Hospitalier Universitaire de Tours, Centre hospitalier universitaire d'Orléans, Vrije Universiteit Brussel, Clinique Pasteur, Pitié-Salpêtrière Hospital, Centre Hospitalier de Bretagne Sud, St George's, University of London, Centre Hospitalier Universitaire de Nantes, Inserm, Université Paris Cité, Hôpital Européen Georges-Pompidou, Paris Cardiovascular Research Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,725
OpenAlex ID: W4416757339