Peripheral chemoreceptors, plant gain, and CO 2 stores as drivers of resting ventilatory control in idiopathic hyperventilation: a prospective case-control study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Patients with idiopathic hyperventilation syndrome (HVS) displayed preserved central chemosensitivity but altered ventilatory control at rest, characterized by elevated ventilation, increased variability, and a leftward-shifted hypercapnic response. These features were strongly associated with peripheral chemosensitivity, CO 2 stores, and reduced plant gain, patterns not observed in controls. These findings support a novel integrative model in which altered CO 2 buffering and peripheral afferent inputs, rather than central mechanisms alone, contribute to ventilatory instability in HVS.
Source: Journal of Applied Physiology
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4416758201