Work

Corneal endothelial changes in type 2 diabetes mellitus with reference to stage of diabetic retinopathy

Year: 2025

Type: article

Abstract: The impact of Type 2 Diabetes Mellitus (T2DM) and diabetic retinopathy (DR) stage on corneal endothelial morphology and central corneal thickness (CCT) remains unclear. In this cross-sectional study conducted at R.L. Jalappa Hospital with 80 participants (40 diabetics and 40 controls), specular microscopy revealed that diabetic patients had significantly lower endothelial cell density, reduced hexagonality and increased coefficient of variation, indicating endothelial dysfunction. Although CCT was slightly thinner in diabetics, the difference was not statistically significant. Moreover, analysis across DR severity (No DR, NPDR and PDR) showed no significant correlation with endothelial parameters, despite a worsening trend with disease progression. Thus, we show that corneal endothelial changes in T2DM may occur independently of DR, underscoring the importance of routine corneal evaluation before intraocular procedures.

Source: Bioinformation

DOI: 10.6026/973206300214226

Authors: U Pramukh Prasad, G Rashmi

Institutions: Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research

Language: English

Topic: Corneal surgery and disorders

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4416758961