Modulation of the Gut Microbiome and Metabolomes by Fermentation Using a Probiotic Complex in a Dysbiosis-Associated Fecal Model
Year: 2025
Type: article
Abstract: . Metabolomic profiling further revealed significant alterations in metabolite levels that may help alleviate gut dysbiosis-related symptoms. These included increases in 3-hydroxybutyric acid, ascorbic acid, cadaverine, L-hydroxyproline, and N-acetylornithine and decreases in lysine and 3-aminoalanine. Given the single-donor design and the use of technical replicates, findings are presented as preliminary and descriptive rather than confirmatory. Collectively, these findings support the potential of probiotic fermentation to modulate microbial composition and metabolic output in a dysbiosis-associated context.
Authors: Hayoung Kim, Hyeon Ji Jeon, Hye Min Jeong, Won Yeong Bang, Han Bin Lee, Kyu-Shik Lee, Jin Seok Moon, Hyeji Kwon, Jongkyun Lee, Jungwoo Yang, Young Hoon Jung
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1562720045, G1619440459, G8664983034
OpenAlex ID: W4416763203