Nutritional Strategies in Preterm Infants: The Role of Human Milk in Bronchopulmonary Dysplasia
Year: 2025
Type: article
Study design: Observational Study
Abstract: AIM: Bronchopulmonary dysplasia (BPD) is a major cause of morbidity and impaired growth in preterm infants. This study compared the incidence of grade 2-3 BPD in infants predominantly fed with mother's own milk (MOM) or pasteurised donor milk (PDM) and examined associations between nutrition and BPD severity. METHODS: Prospective single-centre study including infants < 32 weeks' gestation admitted between January 2023 and June 2024. Infants were classified by predominant feeding type (> 50% MOM or PDM) and BPD severity (no BPD/1 or BPD 2-3). Nutritional intake, feeding tolerance, fortification timing and growth were analysed. RESULTS: Of 158 infants, 88 (56%) received > 50% MOM and 70 (44%) > 50% PDM. BPD 2-3 occurred in 27 (17.1%) infants with no significant group difference (19% vs. 14%, p = 0.41). Feeding intolerance (44% vs. 11%, p < 0.01), delayed fortification (12.5 vs. 7.0 days, p < 0.01), and later enteral feeding (12.0 vs. 6.0 days, p < 0.01) were associated with BPD 2-3. CONCLUSION: No significant difference in BPD 2-3 incidence was found between MOM and PDM groups. Feeding intolerance, delayed fortification, and slower enteral transition were independent risk factors for grade 2-3 BPD.
Source: Acta Paediatrica
DOI: 10.1111/apa.70385
Institution: Hospital General Universitario Gregorio Marañón
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4416764156