Relationship of immune-inflammatory pathway and stress-induced depression with neural regeneration
Year: 2025
Type: article
Abstract: Major depressive disorder is a complex psychiatric condition characterized by mood dysregulation, cognitive impairment, and somatic symptoms. Recent studies underscore the pivotal roles of neural regeneration and inflammation in its pathophysiology. This narrative review synthesizes emerging evidence linking neuroinflammatory pathways and impaired neurogenesis in major depressive disorder. We explore mechanisms including microglial activation, kynurenine pathway dysregulation, synaptic remodeling, and gut-brain axis alterations. Special emphasis is placed on recent discoveries highlighting molecular cross-talk between immune responses and neural plasticity. By mapping these interactions, we aim to advance understanding of major depressive disorder subtypes and support the development of inflammation-targeted therapies.
Source: Neural Regeneration Research
Authors: Qingying Yu, Zhaoyu Chen, Jing Zhang, Yu Cao, Mengjia Sun, Shuyi Ye, Yike Huang, Junchi He, Liping Wang, Kejian Li, Simeng Gu, Peng Sun, Qingjun Zhu, Fushun Wang, Ning Weng, Jason H. Huang
Institutions: Guangzhou University of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong University, Shandong Mental Health Center, SUNY Upstate Medical University, Jiangsu University, Sichuan Normal University, Baylor College of Medicine, Baylor Scott & White Medical Center - Temple, Baylor Scott & White Health
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4416764661