Cold Quad‐Modal Nanocomplex for Precise and Quantitative In Vivo Stem Cell Tracking
Year: 2025
Type: article
Abstract: Current single imaging modalities typically lack the ability to simultaneously offer detailed anatomical visualization and quantitative cellular information, which is crucial for evaluating and improving therapeutic efficacy. This work develops a cold (non-radioactive) quad-modal imaging nanocomplex for magnetic resonance imaging (MRI), magnetic particle imaging (MPI), computed tomography (CT), and multispectral optoacoustic tomography (MSOT) within a single nanoplatform, that is, Albumin-Bismuth-Superparamagnetic iron oxide or ABS. The chemically engineered complex is composed of bovine serum albumin as biocompatible matrix, superparamagnetic iron oxide as MRI and MPI agents, and optoradiopaque bismuth sulfide as CT and MSOT agents. This work demonstrates here its first use for high-resolution, real-time, and quantitative in vivo imaging of mesenchymal stem cells transplanted in mouse brain. This versatile nanocomplex may find applications for non-invasive monitoring cell transfer and cell transplantation in vivo using multiple imaging approaches.
Source: Advanced Functional Materials
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,790
Awards: G1234541941, Upgrade of the 11.7T Research Scanner at the F.M. Kirby Research Center, G2132873222, G4689185066, G6252953675, G6759537411, G7665343622, G779793083, G7923553590, Magnetic Particle Imaging Scanner, Non-Invasive Tracking of Genome-Corrected iPS cells in ALS, G9000081760, G9000275965, Quantitative Dynamic Monitoring of MSCs and MSC-EVs in a Mouse Model of Intracerebral Hemorrhage, Precision magnetic hyperthermia by integrating magnetic particle imaging, Resource for Molecular Imaging Agents in Precision Medicine
OpenAlex ID: W4416764884