Year: 2025
Type: article
Abstract: < 0.001). ROC analysis demonstrated excellent discrimination for SIRS, with AUC values of 0.87 for CRP and 0.86 for CAR and optimal ROC01 thresholds of 2.25 mg/dL and 1.23, respectively. The IDEXX CRP-based SIRS classification showed moderate agreement with the clinical reference (κ = 0.56), whereas a conditional inference tree and logistic regression models confirmed CRP as the most informative variable. The final age-adjusted model including the interaction age × CRP achieved superior performance (AUC = 0.93; κ = 0.84), indicating that CRP's predictive effect varied with age. These results demonstrate that CRP and CAR are complementary, accessible biomarkers for assessing systemic inflammation in CPV infection and suggest that the IDEXX CRP cut-off (>3 mg/dL) may be conservative, as values above 2.25 mg/dL already reflect clinically relevant inflammatory activity.
Source: Veterinary Sciences
Language: English
Topic: Animal health and immunology
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,534
Awards: G1636588721, G2928568735, Laboratório Associado para Ciência Animal e Veterinária, G4770760263, G485358688, Centro de Estatística e Aplicações, G6997658380, Development of decision-supporting models for treatment and prognosis of infectious diseases in dogs and cats, G8008919651, Centro de Investigação Interdisciplinar em Sanidade Animal
OpenAlex ID: W4416765456