Work

Protective Effects of Misgurnus mizolepis Protein Hydrolysate against Atropine-Induced Dry Eye Disease

Year: 2025

Type: article

Abstract: , oral administration of MMH to rats with atropine-induced DED restored tear secretion, preserved ocular tissue architecture, reduced immune cell infiltration, and downregulated inflammatory mediators in the cornea. Furthermore, MMH maintained tight junction proteins, suppressed pro-apoptotic signaling in the lacrimal gland, improved meibomian gland and goblet cell integrity, and mitigated neovascularization. Collectively, MMH demonstrated anti-inflammatory, anti-apoptotic, and tissue-protective effects, supporting its potential as a novel therapeutic candidate for DED.

Source: Journal of Microbiology and Biotechnology

DOI: 10.4014/jmb.2509.09010