Work

The association between miR-632 and major adverse cardiovascular and cerebrovascular events in patients with end-stage renal disease undergoing long-term hemodialysis

Year: 2025

Type: article

Abstract: BACKGROUND: Major adverse cardiovascular and cerebrovascular events (MACCE) are the primary cause of poor prognosis and mortality in patients with end-stage renal disease (ESRD), posing a serious threat to their health. Investigating the risk factors for MACCE in long-term hemodialysis patients with ESRD is of great significance for improving treatment outcomes and patient prognosis. METHODS: Peripheral blood samples were collected from participants, and RT-qPCR was employed to measure the expression levels of miR-632 and PKD1. Participants were followed for three years. The clinical significance of miR-632 in predicting the occurrence of MACCE was analyzed using Kaplan-Meier survival curves, multivariate logistic regression, and ROC curves. RESULTS: In patients with ESRD undergoing long-term hemodialysis, the expression level of miR-632 is significantly elevated. This high expression is strongly associated with an increased incidence of MACCE. miR-632 has high predictive value for the occurrence of MACCE in ESRD patients. CONCLUSIONS: miR-632 is a risk factor for MACCE in ESRD patients undergoing long-term hemodialysis.

Source: BMC Nephrology

DOI: 10.1186/s12882-025-04654-7

Authors: Mei Yang, Li Wang, Yunjian Huang, Jun Long, Shengling Shi

Institutions: Chongqing University, Fuling Center Hospital of Chongqing

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090