Work

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Year: 2025

Type: article

Abstract: Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.-which elegantly connects mechanical stress, inflammation, and vascularity-this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed toward spatiotemporal multi-omics deconstruction of tendon pathology, emphasizing the role of epigenetically driven cellular re-programming in tendon stem/progenitor cells and the emergence of neuro-immune-vascular niches as functional units sustaining chronicity. Furthermore, redox-mechanobiological integration through sensors such as TNIK and the potential of 4D-bioprinted smart biomaterials for chrono-specific therapeutic delivery are explored. By incorporating advanced computational approaches, including AI-powered digital tendon twins, a transformative roadmap is outlined for translating the homeostatic failure model into precisely targeted, mechanism-based diagnostics and therapies. This perspective aims to stimulate interdisciplinary innovation and position tendinopathy research at the forefront of musculoskeletal science.

Source: Advanced Science

DOI: 10.1002/advs.202519568

Authors: DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730