Work

Real-world efficacy and safety of dupilumab in the treatment of head and neck atopic dermatitis: a retrospective cohort study

Year: 2025

Type: article

Abstract: Background: Head and neck atopic dermatitis (HNAD) is a clinically common subtype of AD. While dupilumab is widely used in AD treatment, its efficacy in HNAD is debatable. Objective: This study aimed to evaluate the real-world efficacy and safety of dupilumab in HNAD. Methods: A retrospective study included 29 individuals with HNAD (17 adults and 12 pediatric patients) who were treated with dupilumab. Primary variables, including the Eczema Area and Severity Index (EASI), the Dermatology Life Quality Index (DLQI), Investigator's Global Assessment (IGA), Patient-Oriented Eczema Measure (POEM), Visual Analog Scale for Itch (VAS-Itch), and Visual Analog Scale for Sleep Quality (VAS-SQ), were evaluated at baseline, week 4, week 8, and week 16. Data on adverse events (AEs) were routinely collected. Results: < 0.05) in efficacy indicators, with the exception of children's DLQI, which showed a decreasing trend but did not achieve statistical significance. These findings indicate that dupilumab significantly decreased the severity of the condition and improved the overall quality of life in both adults and children. Conclusion: This real-world study revealed that dupilumab could be an effective and safe therapy for HNAD patients across both children and adults.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1705374

Authors: Zifan Li, Junsheng Peng, Ruoxi Yu, Ying Lin

Institutions: Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801