Low expression and significance of AOC1 in prostate adenocarcinoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Currently, amine oxidase copper-containing 1 (AOC1) is less studied in cancer. There are few studies on the relationship between AOC1 and prognosis in prostate cancer. This study explores the expression profile of AOC1 in normal prostate tissue and prostate cancer, and investigates the relationship between the expression of AOC1 and prognosis of prostate cancer. Methods: The expression of AOC1 in 101 prostate cancer tissues and 22 normal prostate tissues was detected by immunohistochemistry. The AOC1 protein levels in the urine and blood samples of patients with prostate adenocarcinoma were examined by independent samples t-test. Results: AOC1 had a low positive expression rate (4.0%, 4/101) in prostate adenocarcinoma tissues, which was significantly lower than that (90.9%, 20/22) in adjacent normal tissues. The cancer-specific survival (CSS) for AOC1-positive patients was significantly shorter than those with AOC1-negative tumors (31.750±8.384 vs. 79.068±4.818 months, P<0.001). Cox multivariate regression analysis showed that AOC1 positivity was the only survival factor of both cancer-specific survival (P=0.005) and progression-free survival (P=0.01). The AOC1 protein levels in the urine and blood samples showed no significant differences between preoperative prostate cancer patients and three months after operation of prostate cancer (P=0.43, P=0.41, respectively). Cell culture showed that downregulation of AOC1 resulted in significant reduction of migrated PC3 cells. Conclusions: AOC1 has low expression in prostate adenocarcinoma, and its positive expression may be associated with tumor prognosis.
Authors: Hong-Qun Wang, De-Lun Yan, Hao-Ming Hua, Cong Huang, Wei Sun, Ya-Nan Zhu, Na Yu, Jing Shen, Zhi-Hou Ma, Si-Zhen Tao, Yan Huang, You-Jie Gong, Yang-Yang Zhang
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4416772687
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