The dynamics of neuromuscular resilience across the lifespan: Ageing, disuse and intervention
Year: 2025
Type: article
Abstract: The integrity of the neuromuscular system (NMS) is a critical determinant of human mobility, health and safety over the life span.Its function, however, is continuously contested by a confluence of biological stressors: primarily intrinsic progressive biological ageing, acute periods of disuse and the molecular perturbations induced by chronic disease.This special issue of The Journal of Physiology is dedicated to dissecting these challenges, offering a collection of innovative original research, translational reports and essential technical advancements that collectively advance our understanding of the NMS from the supraspinal cortex to the molecular dynamics of the myocyte.This compilation is structured around three core pillars: Vulnerability, which explores the fundamental biological mechanisms of pathological decline; Acute Stress, which investigates the rapid and C. Centner and R. Ritzmann contributed equally to this work and share first authorship.U. Marusic and L. Hughes contributed equally to this work and share last authorship.maladaptive changes induced by physical inactivity; and Resilience, which assesses the efficacy and mechanistic underpinnings of targeted physiological interventions.Collectively, these articles illuminate the remarkable, yet diminishing, plasticity inherent in the motor system, and critically, how this plasticity may be harnessed to safeguard functional capacity throughout life.Vulnerability: unravelling the intrinsic mechanisms of decline and pathology
Source: The Journal of Physiology
DOI: 10.1113/jp290276
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4416773199