Work

Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa

Year: 2025

Type: article

Study design: Observational Study

Abstract: α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology.

Source: npj Biofilms and Microbiomes

DOI: 10.1038/s41522-025-00850-3

Authors: Lisa Bremard, Lisa Wallart, Emilie Lahaye, Mohamed Amine Ben Mlouka, Jochen Seitz, Beate Herpertz-Dahlmann, Sergueï O. Fetissov

Institutions: Inserm, Neuroendocrine, Endocrine and Germinal Differentiation Communication, Université de Rouen Normandie, Centre National de la Recherche Scientifique, High-tech Research infrastructures for Life Sciences, Essen University Hospital, Universitätsklinikum Aachen, RWTH Aachen University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,290

Funders: European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Région Normandie

Awards: MIGBAN - Interaktion zwischen Darm-Mikrobiom und Gehirn bei Anorexia Nervosa- Teilprojekt Mikrobiomanalysen, MIGBAN - Interaktion zwischen Darm-Mikrobiom und Gehirn bei Anorexia Nervosa - Teilprojekt Translationale Studien zur Rolle von mehrfach ungesättigten Omega-3-Fettsäuren und Psychobiotika, G7111637461

OpenAlex ID: W4416773719

FWCI: 0.261

Cites: 23

Cited by: 1

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