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Evaluation of Aminoglycoside Dosing Regimens Adjusted for Renal Function and In Vitro Susceptibility Test Interpretive Criteria for Enterobacterales and Pseudomonas aeruginosa : Brief Summary

Year: 2025
Type: article
Abstract: The results of pharmacometric analyses for aminoglycosides were used to support recommendations for dosing regimens adjusted for renal function and a reassessment of the United States Committee on Antimicrobial Susceptibility Testing susceptibility test interpretive criteria for Enterobacterales and Pseudomonas aeruginosa. Susceptible and susceptible-based on therapeutic drug monitoring breakpoints are recommended for extended-interval amikacin, gentamicin, and tobramycin dosing regimens, thus representing adaptable treatable approaches.
DOI: 10.1093/ofid/ofaf427
Authors: Sujata M Bhavnani, Jeffrey P Hammel, Nikolas J Onufrak, Jason M Pogue, Ronald N Jones, Helio S Sader, George L Drusano, John S Bradley, David R Andes, William A Craig, Paul G Ambrose
Institutions: Institute for Clinical Pharmacodynamics (United States), University of Michigan, JMI Laboratories, University of Florida, University of California San Diego, Rady Children's Hospital-San Diego, University of Wisconsin–Madison
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W4416775359
FWCI:
Cites: 14
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